Grab yourself a pocket microscope (at least 60x magnification) and take a close look at the trichomes. If the heads are mostly still clear, you need to wait a bit longer. If they're milky, you can harvest if you don't want too much of a hit on your body. If you prefer a more stoned effect, wait until about 20 to 40 percent are amber and the rest are milky. From my experience, most people harvest when they're milky and 20 percent amber. But you should always wait at least until the trichomes are milky. Oh, and when you're looking at the buds with a microscope, focus on the flowers, not the sugar leaves.