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Looks liked powdery mildew. Make sure your grow space humidity is in around 50%. Google powdery mildew treatments and it can help. Also check the cannabis leaf deficiency chart on google as well.
Es posible que sea una quemadura provocada por el exceso de algún nutriente, puede haber desajuste de ph también, si es hoja vieja no pasa nada, si es nueva vigila el abono.