i agree with ez, symmetry helps.. a plant doesn't grow oblong on its own and likely results in some waste... 4 plants would be easier in future to fill space efficiently with least wasted effort and time.
you can mitigate it, though. train and bend more branches to go out on the long axis (4'). Shorter branches trained to the shorter axis (2') becuase those will need more time to fill out. Can fiddle with apical dominance too... allow something to gain dominance that needs more growth to catch up.. then bend and tie it back down to normal level of canopy... obviously, if you do that you need to get it bent back down before the stem becomes rigid.
be systematic, no matter what the context... work backward from what you want (X colas per 4"x4" to 6"x6" or whatever) This will help you organize better early on. you obviously need more growth on the long-axis to fill it in in the same time period as the short axis. (per 2'x4' plant...) and if one area fills in faster, can prune off extra growth while you wait (wasted tme, but can be minimized)
have a plan... revise it based on how it goes... before long you'll have a process involving a few basic tenets to follow