definitely 1.. autos are variable in size and definitely larger than 1'x1' each. Even though an auto will not fill an entire 2x2 space all the time, this leaves room for a fan or any other equipment.
guess you could do 4 and prune to fit, but with autos this wouldn't save time. With photos 12/12 from seed, you may be able to fit 4 in there, but probably still have to prune them to fit. This might shave a couple weeks compared to most autos.. which usually take 84 days give or take regardless of what breeder says. just a photo with a 21 day vege or so.