If it's under a bunch of foliage, the leaf may be dying off due to lack of light.
If it gets plenty of light, it may not have received enough nitrogen during its pre-flower stretch. Cannabis plants, "stretch," for the first 3-4 weeks of being under 12 hours of light and 12 hours of darkness. So, you have to make sure to give them enough nitrogen to make it through the stretch, as well as the rest of flower. It can be tough because every cultivar is different, just like every phenotype.
It could also be chalked up to basic fade, which the plant does towards the end of it's life cycle. Fade is when the plant basically starts eating itself.