HST at week 2.5 in flower?

Hi! I think it's better to supercrop the tallest branches than let them suffer from the lights being too close for the rest of the grow. If your plant is healthy otherwise, it shouldn't even notice it so you can supercrop at any given time IMO. I did it to many of my branches whenever they get too close to the light too

Ideally you would have wanted to start 1-2 weeks ago but I think the plants closing in on the light trumps any issue you might have. I personally would get a trellis net and start hooking those tall branches under the trellis to even out the canopy and keep it away from the light. From there just keep pruning her a bit to ensure light is reaching all buds. Hope this helps!