There should be directions on the bottles I would follow those to a T, I know the neem oil I use it says 3-4 application at 72 hour intervals to get rid of pest then once a week after that. And always test whatever your using out on a couple leaves before you coat her in whatever your using as some stuff isn’t safe. And make sure you have something for flowering, you can’t use some stuff during flowering neem oil is one of them