I was told you can do it up until the end of the third week of flower, but another also suggested he saw better results if he did it all before flipping and then just letting them go till his final defoliation before harvest.. the choice is really up to you if you feel they are blocking bud sites or the canopy is just too think for good air movement. It's your call but i'd say do it now.. It's only going to get bushier!! Happy growing!