Hey there , as with any cannabis plant most of the defoliation should be done in veg only, really depends what you want to do. For example you can defoliate in order to keep it in veg by removing any leaf that's starting to split into five tips, this gives you extra time for extreme training. You can also try to defoliate to maximize yield, this you do by identifying potential flower nodes and you remove any leaf that s shading that spot so that the flower gets light (the plant thinks that it's grown tall enough and pushes out the flower) you can also defoliate the lower leafs on the branches so that energy is not wasted on the lower bud sites likely to end up as popcorn nugs anyway. The main thing you can do is once the plant flowers then take a razor blade and remove the bottom one or two flower nodes as they appear so that all the energy gets concentrated to the flowers on the upper parts of the colas making them bigger and improving the average quality of your yield. Hope this helps ! 🚀