negative pressure is totally fine, but basically it simulates different altitudes, and this affects the VPD charts. with less pressure you need less moisture or temperature or something to get it right, but it's like that : since we dont know there s a drop in performance. dial it in correctly and it's really no big deal. The easiest is to play with the humidity and see for yourself . learn more about VPD and how it controls metabolism here : https://pulsegrow.com/blogs/learn/vpd Hope this helps ! 🚀