i'd do 1 or 4... if those are cm, i'd stick to one.
symmetrical plants are easier to shape, in my opinion. 1plant, 2x2=4 plants 3x3=9 plants and so on for a square space. But, you can shape it any way you want. If you LST it, they might be oblong anyway. in this case 2 plants might be a great idea. You can do any # you want, simply fill about 1/2 the space before flipping to 12-12 if photoperiods (about 3/4 length by 3/4 width = ~1/2). ! cola per 6 in^2 is a good goal to shoot for.