If I’m going to do it.. which after more and more experience, I do much less than I used to.. but if I’m going to do it I do it around day 21 of flower.
At that point, most your stretching and veg growth is done so you have a good sense of the final structure of the plant. Taking half of the fans is way too much IMO - tho there are exceptions to the rule. I’d say go for like 15-25% max.
That said, you’ll hear all types of arguments on here as to what is the right way to go with defoliation.. just trust your gut as far as what makes sense to you.. and see how that works out. Adjust next grow according to your results here.
Cannabis cultivation culture is so full of misinformation and myth.. again, trust your gut and learn from experience.