Yes, of course it can! As long as you're working with stems that are pliable enough! I had to LST my Tangerine Dream 2 weeks before harvest because she was trying to grow through the top of my tent! I ended up doing an accidental HST on one stem and she acted like nothing had happened... Then, I had to try to move my light up on top of the cross bars of my tent and the light, you guessed it, slipped and crashed down almost breaking the main cola off completely... taped it back together and she didn't even blink.... so LST in the 2nd week of flowering? Absolutely...
Good luck!