You can certainly defoliate if you need to - and with this one, I definitely WOULD .. you've got a lot of buds that are being denied good light and won't develop into good ones if they don't get the light! Go slowly with autos - do a bit today, a bit more tomorrow when you see how she's reacting (or not!). A good article on the whole subject is here if you want... https://www.growweedeasy.com/nebulas-super-simple-3-step-defoliation-tutorial
Good luck! Gorgeous looking grow!