Hey
@Chewyyyy! I usually avoid any kind of pruning/defoliation after the 2nd week of flowering, because I want my plants to drive their energy into bud fattening and resin production, rather than recovery. But this isn't 100% true, sometimes it's better to defoliate if the leaf is really creating shade onto some potential big bud. To summup, do it intelligently and slightly, and you should see great results! Happy growing 👊