Sure, after 3 weeks of flowering, you can remove leaves, do Lollipopping/defoliation, and trim any underdeveloped branches at the bottom of the plant. You can confidently clean your plant; after 3 weeks, growth stops and the plant just ripens. The large fan leaves are solar panels that have already utilized more than 50% of their potential. If you're worried and unsure about cutting or not cutting, just remove the most problematic leaves that are causing the most obstruction. You can also bend the leaves or roll them up. In my opinion, it's better to remove leaves that shade the branches and hinder their development. If you leave the leaves and let them shade the neighboring branches, you risk getting a) lower yield and b) a risk of mold and mildew. Removing large leaves promotes good air exchange within the plant.