They're a little small (not the leaves - the plants!) to do any defoliation... what I would do (and what I do myself at this stage) is to tuck those large leaves under and get them out of the way or tie them down much like the LST process... they're still there, still providing photosynthesis to the plant, still moving nutes around and in general providing the plant with what it needs. As the plant gets much taller and more into bloom, you can trim a few of them if you need more airflow. I generally will trim fan leaves that grow toward the main stem but only when they're a few weeks into bloom.
You're going to have a monster plant by the looks of those leaves! Enjoy!!